Abstract:ObjectiveTo study the protective effect of diammonium glycyrrhizinate injection(DG)on renal ischemia/reperfusion (I/R) in rats.MethodsA model of renal I/R was made by clamping double renal pedical for 60 min and reperfusion for 24 h. The injection of DG (15mg/kg or 30mg/kg) was pretreated before renal ischemia. The leveles of serum urea nitrogen (BUN), serum creatinine (Scr), tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1) in serum were detected after reperfusion for 1 h and 24 h respectively, and the content of MDA and SOD in renal tissuses were measured after reperfusion for 24 h.ResultsDG significantly decreased the level of BUN and Scr, decreased the concentration of TNF-α and IL-1 in serum. Pretreatment with DG also enhanced the activity of SOD, reduced the concentration of MDA in renal after I/R.ConclusionDG has significant protective effect on renal I/R and markedly improve the renal function. The mechanisms are associated with decrease the lipid peroxidation reaction and reduce the level of TNF-α and IL-1.
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