The Effects of Oxymatrine Inhibiting Airway Inflammation and Airway Hyperreactivity in Asthmatic Rats
Abstract:ObjectiveTo investigate the effect of oxymatrine(Oxy) on astimatic rats.MethodsForty eight SD rats were randomly divided into six groups:the control group(A), the asthma model group(B), the dexamethasone treating group(C) and Oxy low dose(D), middle dose(E), high dose(F) treating groups. The asthmatic model was established by sensitization and challenge with ovalbumin. The hemomyelogram of peripheral blood were detected. We observed the pathomorphological changes of lung tissue through HE dyeing and recorded the lung outflow volume in vivo and the contractile response of trache-spiral-strip ex vivo to tacetylcholine(ACH) through power lab system.Results(1)The numbers of eosinophil(EOS) of peripheral blood in group B were higher than that in the other groups (P<0.01).(2)The lung tissues of group B showed inflammatory reaction which was severer than that of the other groups(P<0.01).(3)The changes of lung outflow volume and the contractile response of trache-spiral-strip to ACH were lower in group D, E and F than that in proup B(P<0.01). Compared with group A, these results of group E and F had not obviously difference (P>0.05).ConclusionOxy may inhibit airway inflammation and depress airway hyperreactivity of asthmatic rats and have positive effect of anti-asthma.
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