Inhibitory Effects of Portulaca oleracea L. on Hepatocellular Carcinoma HepG-2 Cells
Abstract:Objective To investigate the inhibition of Portulaca oleracea L. on proliferation hepatoma HepG-2 cells.MethodsMTT assay was used to examine the effect of Portulaca oleracea L. on the proliferation of HepG-2 cell and flow cytometry was used for the cell cycle distribution.ResultsPortulaca oleracea L. inhibited the proliferation of HepG-2 cell and the effects were in a time-concentration dependent manner. Portulaca oleracea L. also induced apoptosis, the Sphase was arrested. There was significantly difference in the ratio of apoptosis from control group. ConclusionPortulaca oleracea L. inhibits proliferation of HepG-2 cells via induction of apoptosis and cell cycle arrest.
Key words:Portulaca oleracea L. ; Cell cycle; Apoptosis