Abstract:In this paper a new research strategy of “TCM Genomics”is proposed on the basis of achievements and advances in the fields of HGP, biochip proteomics,biotechnology and modern analytic technologies. In order to elucidate the action or function of TCM with its regulation to a group of genes that represent this action or function. We presume that modernization of TCM should focus on TCM Genommics and apply gene technology centred upon gene chip to TCM Genommics and modern research of TCM.
Key words:Gene chip; TCM Genommics; Modernization of TCM
[9]Drews J. Genomic sciences and the medicine of tomorrow[J].DDT.2000,5(1):2.
[10]Roses AD.Genome-based pharmacoge-netics and the pharmaceutical industry.Nat Rev Drug Discov,2002,1(7):541.
[11]Mandel S,Weinreb O,Youdim MB.Using cDNA microarray to assess Parkinson's disease models and the effects of neuroprotective drugs[J].Trends Pharmacol Sci,2003,24(4):184.
[12]Yin X,Zhou J,JieC,et al.Anticancer activity and mechanism of Scutellaria barbata extract on human lung cancer cell lineA549[J].Life Sci,2004,75(18):2233.
[13]Bonlmm M,Arnold H,Montgomery B,et a1.Molecular effects of the herbal compound C-SPES:identification of tivitypathwaysinprostate carcinoma [J].Cancer Res,2002,62(14):3920.
[14]Lee GJ,Lee WS,Jeon KS,et al.cDNA Microarray Exprssion Analysis and Toxicological Phenotype for Anticancer Drug[J].J.Vet.Med.Sci.2004,66(11):1339.
[15]Steven J,Bulera SM,Eddy E,et al.RNA expression in the early characterization of hepatotoxicants in Wister rats by high-density DNA microarrays[J].Hepatology,2001,33:1239.
[16]Kiela PR,Midura AJ,Kuscuoglu N,et al.Effects of Boswellia serrata in mouse models of chemically induced colitis[J].Am J Physio Gastrointest Liver Physiol,2005,288(4):798.
[17]Htratsuka M,Ebisawa A,Matsubara Y, et al.Genotyping of Single Nucleotide Polymorphisms(SNPs) Influencing Drug Response by Competitive Allele-spcific Short Oligonucleotide Hybridization (CASSOH) with Immunochromatographic Strip[J].Drug Metab Pharmacokin, 2004,19(4):303.
[18]Hirohisa Saito. Translation of the human genome into clinical allergy[J].Allergology International,2003,52: 65.
[19]Debouck C, Goodfellow PN .DNA microarrays in drug discovery and development[J].nature genetics supplement,1999,21:48.
[20]Pollard HB,Eidelman O,Jacobson KA.Pharmacogenomics of cystic fibrosi[J].Mol Interv,2001,1(1):54.
[21]Lymberis SC,Parhar PK, Katsoulakis E.Pharmacogenomics and breast cancer [J].Pharmacogenomics, 2004, 5(1):31.
[22]Anno S, Kudo S, Hamasaki K,et al. Techniques of SNP Genotyping and Remote Sensing Applied for Elucidation of the Contribution of Polygene and Environmental Factors to Inter-individual Variation in Skin Pigmentation Phenotype[J].J Physiol Anthropol Appl Human Sci, 2005,24: 483.
[23]Weinstein JN.Pharmacogenomics-teaching old drugs new tricks[J].New Engl J Med.2000,343:1408.