Abstract:ObjectiveTo prepare temperature_sensitive situ gel of Ligustrazine Hydrochloride based on Poloxamer 407, which will be used in abdominal cavity, and establish its evaluation method in vitro.MethodsPrepare solution of Poloxamer 407 in different concentrations, measure their phase transition temperature, draw viscosity-temperature curve, determine drug release rate in vitro at the body temperature and choose the proper situ gel formulation according with the pathological characteristic of abdominal cavity adherence.ResultsThe optimizing formulation was Poloxamer 407 situ gel at 40%(w/w) combining with MC at 2%~3%(w/w), which prolonged Ligustrazine Hydrochloride release time in vitro.ConclusionThe prepared situ gel posseses favorable drug release performance, temperature sensitivity and viscosity. The method is simple and reproducible.
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