Abstract:AIM To investigate the effects of fluvastatin on transforming growth factor beta1 (TGF-beta1 )in rats with ra-diation-induced lung injury.METHODS SD rats were divid-ed randomly into3groups:normal control,irradiated con-trol,rats irradiated and treated with fluvastatin.Two groups of rats were irradiated with x-rays at a dose of20Gy thoraci-cally.Seven days before the irradiation the rats in the fluvas-tatin group started the treatment with fluvastatin at a dose of20mg per day by garaging and continued to the end of the ex-periment.Tissues of lung were fecthed at different times.TGF-beta1 expression was measured by immunohis-tochemicall staining.RESULTS There was a significantly increase in the expression of TGF-beta1 in association with the increase of time in the irradiation group.The expression of TGF-beta1 in the irradiation-treatment group was dim,compared with the irradiation group.CONCLUSION Flu-vastatin down-regulated TGF-beta1 expression,which indi-cated that the degree of irradiation-induced lung injury was reduced.